InterPAD - DETAILS

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General Info
Effects Info

Synergistic

Reference

Drug Interaction Details

01. General Information

Pair Name	Mahanine, Cisplatin
Phytochemical Name	Mahanine (PubChem CID: 36689305 )
Anticancer drug Name	Cisplatin (PubChem CID: 5702198 )
Structure of Phytochemical			Download 2D MOL 3D MOL
Structure of Anticancer Drug			Download 2D MOL 3D MOL

02. Combinatorial Therapeutic Effect(s)

Synergistic Effect

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Decreasing Drug Toxicity

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The theory of cold and heat

Drug Name	Cisplatin
Adverse Reactions	Myelosuppression, dry mouth and throat, fever, dry stools. This was inferred hot nature anticancer drug.
Recommendations	Cold: Anemarrhena asphodeloides; Urena lobataL; Artemisia scoparia; Swertia mussotii; Swertia pseudochinensis; Gentiana manshurica; Gossampinus malabarica; Pyrrosia sheareri; Pyrrosia sheareri; Iris domestica; Gentiana scabra; Pyrrosia sheareri; Pyrrosia petiolosa
Reference	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　`ref_link`

Combination Pair ID: 508

Ref_1

Pair Name	Mahanine, Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Cleavage	BID	hsa637
	Down-regulation	Cleavage	CASP8	hsa841
	Down-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Phosphorylation	JAK1	hsa3716
	Down-regulation	Expression	JUN	hsa3725
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Phosphorylation	SRC	hsa6714
	Down-regulation	Phosphorylation	STAT3	hsa6774
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
In Vitro Model	SiHa	Human papillomavirus-related cervical squamous cell carcinoma	Homo sapiens (Human)	CVCL_0032
Result	Our results revealed that mahanine may be a prospective agent to reduce the concentration of cisplatin in adjunct for the treatment of cancer and thereby decreasing its toxicity.

03. Reference

No.	Title	Href
1	Improved chemosensitivity in cervical cancer to cisplatin: synergistic activity of mahanine through STAT3 inhibition. Cancer Lett. 2014 Aug 28;351(1):81-90. doi: 10.1016/j.canlet.2014.05.005.	`Click`

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